Dr. Chang is the founder and medical director of the nascent Medical Intelligence and Innovation Institute (MI3) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to implement data science and artificial intelligence in medicine and is the first institute of its kind in a hospital. The new institute is concomitantly dedicated to facilitate innovation in children and health care all over the world. He is the founder of the Medical Intelligence and Innovation Summer Internship Program, which mentors close to 100 young physicians-to-be every summer. Dr. Chang has also published review papers on big data and predictive analytics as well as machine learning and artificial intelligence in medicine. He is currently organizing a book project, Medical Intelligence: Big Data, Predictive Analytics, Cognitive Computing, Machine and Deep Learning and Artificial Intelligence in Medicine. He is the organizing chair for the Artificial Intelligence in Medicine (AIMed) annual meeting, the largest meeting that focuses on applications of artificial intelligence in medicine.